A high percentage of body fat makes the flu more dangerous

A healthy percentage of body fat reduces the likelihood that someone who has caught the virus will die from the flu. Such conclusions follow from an animal study that nutritionists at the University of North Carolina published in 2007 in the journal of Nutrition. Such studies, for obvious reasons, are not conducted on humans.

Study of the influence of obesity on infections and immunity
If you are overweight your immune system is at risk. This is all because fat layers can't be large and healthy at the same time. Fat cells that have accumulated too much fat die and must be removed by immune cells. This is why there is an increased concentration of inflammatory factors such as IL-6 and TNF-alpha in the blood of obese people. The researchers wanted to know whether a deregulated immune system makes the body more vulnerable to flu viruses.

Methods of research on mice
The researchers divided the C57BL/6J mice into two groups. One group received food containing added sugar and fat for 22 weeks. Therefore, the mice in this group gained a lot of weight due to fat. The other group received normal food and remained fairly slim. At the end of 22 weeks, researchers infected mice with an aggressive flu virus. Ten days after being infected with the flu virus, 42% of the fattened mice were no longer alive. Of the normal-weight laboratory mice, only 5.5% died. This means that the flu virus was almost seven times more deadly for fat mice than for normal ones.

Three days after they were infected with the flu virus, the researchers extracted immune cells from the lungs of mice and placed them in different concentrations [E:T] in test tubes along with cancer cells. Normally, natural killer cells [in this case, they were of the CD3-DX5+ type] attack cancer cells, and this is what happened in the test tubes. The figure on the left below shows that natural killer cells destroyed more cancer cells in lean mice than in fattened ones.

Conclusion: obese mice are 7 times more likely to die from flu
"The importance of the current findings is highlighted by the fact that millions of people around the world suffer from flu every year, and the global prevalence of obesity has reached epidemic proportions," the researchers write. "In this study, we found that obesity led to dysregulation of innate immune responses to flu infection and increased mortality. Since the innate immune response also activates and polarizes the corresponding cellular mediated response, these data indicate that overall immune function may be affected by obesity. In addition, these data suggest that in addition to influenza infection, obesity may increase susceptibility to other viral infections by dysregulating the immune system."

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