Effect of hormones during exercise on muscle hypertrophy

And the adaptation of muscles to the load in the form of hypertrophy is regulated more by intracellular changes than by external stimuli coming from anabolic hormones. However, this is true only in cases where the concentration of anabolic hormones is within the normal physiology of a person. Artificially inflated many times the hormone levels already significantly affect the hypertrophy of muscle cells.

Natural, physiological concentrations are almost not responsible for muscle growth in response to strength training. Research shows that both temporary acute changes in hormone levels in response to stress and long-term chronic changes, both in the greater and lesser direction, do not significantly affect adaptive hypertrophy. Physical activity initiates the activation of signaling pathways in muscle cells that control enzymes responsible for protein synthesis. In addition, directly inside the cell in response to the load, hormone-like substances are formed – mechanical growth factor, insulin-like growth factor.

Their effect on muscle cells in relation to protein metabolism is similar to that of somatropin and insulin combined. Reduced decay and increased synthesis. It is interesting that such local changes in response to load are stored in the muscles until old age. Therefore, when sarcopenia – age-related loss of muscle mass and strength, despite the natural decline in the level of anabolic hormones (testosterone, growth hormone), recommend training with weights. They successfully resist it. Both strength and muscle mass increases. Just like physical activity is recommended for people with diabetes. Inadequate work of insulin or its lack is compensated by physical activity, which, as mentioned above, can duplicate hormonal effects, and in addition increase sensitivity to hormonal signals.

Do physical activities make sense for hormonal disorders?
That is, for people with endocrine pathologies and abnormalities, the load is even an integral part of treatment. Why, then, does a healthy person wonder if training makes sense for hormonal failure? They have, and their effectiveness will not be significantly limited, since the muscles have hormone-independent mechanisms of adaptation and response to stress.

But if the loads themselves are the cause of hormonal failure, then it is better to be careful and review your training program, diet and rest regime.

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