How to use Mildronate in bodybuilding

MILDRONATE is a medication that is used in medicine for heart failure problems. Due to the fact that such "insufficiency" (overstrain) occurs in the practice of sports, Mildronate, or rather Meldonium, which is the active substance of the drug, is also used by athletes.

Mildronate is sometimes also called "Russian L-carnitine". "Russian" - because it was invented in 1976 in Latvia, which at that time was part of the USSR, and "L-carnitine" - because its principle of action is directed to the same mechanism as that of L-carnitine – the transport of fatty acids (LC) inside the mitochondria (MX).

Since 2016, Meldonium has been listed as a prohibited drug by the WADA anti-doping Agency. In particular, Russian athletes such as tennis player Maria Sharapova, 4-time world champion in swimming Yulia Efimova, and boxer Alexander Povetkin had problems with Meldonium. The question of attributing the drug to doping is ambiguous, since Western athletes almost do not take" Russian L-carnitine", in doping tests of Russian athletes Meldonium was present in 17% of cases and in fact more than 200 athletes from the former CIS countries were disqualified for using this drug. However, since 2016, Meldonium is a dope.

Mildronate: how it works

L-CARNITINE is a well-known, proven Supplement that has numerous studies on its use both in sports and in clinical practice. It optimizes the delivery of fatty acids inside the cell organelles-mitochondria. The MH produces ATP energy, on which cells function. In fitness, L-carnitine is commonly used as a fat burner, in clinical practice it is a cytoprotector, an antihypoxant that optimizes the work of cells, primarily heart cells.

Meldonium, in fact, as L-carnitine, is also a cytoprotector, antihypoxant and" optimizer " of cellular metabolism. It also, like L-carnitine, affects the mechanism of entering the LC inside the mitochondria, however, in fact, Meldonium is not an analog of L-carnitine, it is its ANTAGONIST! Meldonium, in contrast to L-carnitine, does not contribute to the flow of LC inside the mitochondria, it BLOCKS this flow!

Information about what is the principle of action of Meldonium, you can get from the instructions of the drug:

"Meldonium, being a structural analog of gamma-butyrobetaine (GBB), has a competitive inhibition (blocking) of GBB-hydroxylase — the last enzyme in the chain of L-carnitine biosynthesis in humans and animals. From its influence, the synthesis of L-carnitine is inhibited, and, accordingly, the transport of long-chain fatty acids through the cell membranes of mitochondria. When blocking transport inside LCD MX cell metabolism switches to glucose oxidation, which results in lower energy costs for the cells, reduces the appearance in the cell of toxic compounds, reduced oxidative stress. This mechanism is especially relevant in the conditions of ischemic myocardium. Thus, when using the drug Mildronate, the manifestations of chronic heart failure (CHF) decrease, the contractile function of the heart improves, and, consequently, the tolerance to physical activity.»

So, the General meaning of the action of Meldonium is that it switches the cell's metabolism from fat oxidation to carbohydrate oxidation, while optimizing the production of ATP energy (read: increases aerobic capacity), which reduces the load on the heart muscle.

The General meaning of the drug, in General, is clear. Now it would be good to clarify the particulars:

FIRST, why (how?) switch from fat oxidation to carbohydrate oxidation is to optimize the production of ATP?
SECONDLY, how will Meldonium work on the "sports" heart? Does all types of load have a justification for its acceptance, or only in certain types?
THIRD, what is the Protocol for taking the drug? Are there any restrictions on accepting it? Looking ahead, we must say that there are restrictions, in fact, and the conversation here is not that this is doping – a matter of pure biochemistry of its work.

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